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Amyloidosis is a rare disease that occurs when substances called amyloid proteins build up in your organs. Amyloid is an abnormal protein usually produced by cells in your bone marrow that can be deposited in any tissue or organ.

Amyloidosis can affect different organs in different people, and there are many types of amyloid. Amyloidosis frequently affects the heart, kidneys, liver, spleen, nervous system and gastrointestinal tract.

The exact cause of amyloidosis is unknown, and there's no cure for amyloidosis. However, therapies are available to help you manage your symptoms and limit the production of amyloid protein.